Dementia Drug Development

A patient's pre-existing level of functioning is impacted by a progressive, irreversible decline in cognition, which is referred to as dementia. There are numerous aetiologies for dementia, with Alzheimer's disease being the most prevalent (AD). An expanding amount of research on the pathophysiology of Alzheimer's disease serves as the foundation for drug development in the condition. Currently being pursued disease-modifying strategies include targeting insulin signalling, neuroinflammation, tau aggregation, amyloid processing, and neurotransmitter dysfunction, with varying degrees of success. Because of its dominance at the pathophysiological stage, the amyloid cascade is essential to many novel treatment strategies.

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